Early immune responses and development of pathogenesis of avian infectious bronchitis viruses with different virulence profiles
Identifieur interne : 000F16 ( Main/Exploration ); précédent : 000F15; suivant : 000F17Early immune responses and development of pathogenesis of avian infectious bronchitis viruses with different virulence profiles
Auteurs : Cintia Hiromi Okino [Brésil] ; Marcos Antônio Zanella Mores [Brésil] ; Iara Maria Trevisol [Brésil] ; Arlei Coldebella [Brésil] ; Hélio José Montassier [Brésil] ; Liana Brentano [Brésil]Source :
- PLoS ONE [ 1932-6203 ] ; 2017.
Abstract
Avian infectious bronchitis virus (IBV) primarily replicates in epithelial cells of the upper respiratory tract of chickens, inducing both morphological and immune modulatory changes. However, the association between the local immune responses induced by IBV and the mechanisms of pathogenesis has not yet been completely elucidated. This study compared the expression profile of genes related to immune responses in tracheal samples after challenge with two Brazilian field isolates (A and B) of IBV from the same genotype, associating these responses with viral replication and with pathological changes in trachea and kidney. We detected a suppressive effect on the early activation of TLR7 pathway, followed by lower expression levels of inflammatory related genes induced by challenge with the IBV B isolate when compared to the challenge with to the IBV A isolate. Cell-mediated immune (CMI) related genes presented also lower levels of expression in tracheal samples from birds challenged with B isolate at 1dpi. Increased viral load and a higher percentage of birds with relevant lesions were observed in both tracheal and renal samples from chickens exposed to challenge with IBV B isolate. This differential pattern of early immune responses developed after challenge with IBV B isolate, related to the downregulation of TLR7, leading to insufficient pro-inflammatory response and lower CMI responses, seem to have an association with a most severe renal lesion and an enhanced capability of replication of this isolate in chicken.
Url:
DOI: 10.1371/journal.pone.0172275
PubMed: 28199419
PubMed Central: 5310907
Affiliations:
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xml:lang="fr">Brésil</country><wicri:regionArea>Embrapa Swine and Poultry, Concórdia, SC</wicri:regionArea><placeName><region type="state">Santa Catarina</region></placeName></affiliation></author><author><name sortKey="Mores, Marcos Antonio Zanella" sort="Mores, Marcos Antonio Zanella" uniqKey="Mores M" first="Marcos Antônio Zanella" last="Mores">Marcos Antônio Zanella Mores</name><affiliation wicri:level="2"><nlm:aff id="aff001"><addr-line>Embrapa Swine and Poultry, Concórdia, SC, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Embrapa Swine and Poultry, Concórdia, SC</wicri:regionArea><placeName><region type="state">Santa Catarina</region></placeName></affiliation></author><author><name sortKey="Trevisol, Iara Maria" sort="Trevisol, Iara Maria" uniqKey="Trevisol I" first="Iara Maria" last="Trevisol">Iara Maria Trevisol</name><affiliation wicri:level="2"><nlm:aff id="aff001"><addr-line>Embrapa Swine and Poultry, Concórdia, SC, 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Department of Veterinary Pathology, Universidade Estadual Paulista—UNESP, Jaboticabal, SP, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Laboratory of Immunology and Virology (Imunovir), Department of Veterinary Pathology, Universidade Estadual Paulista—UNESP, Jaboticabal, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Brentano, Liana" sort="Brentano, Liana" uniqKey="Brentano L" first="Liana" last="Brentano">Liana Brentano</name><affiliation wicri:level="2"><nlm:aff id="aff001"><addr-line>Embrapa Swine and Poultry, Concórdia, SC, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Embrapa Swine and Poultry, Concórdia, SC</wicri:regionArea><placeName><region type="state">Santa Catarina</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Avian infectious bronchitis virus (IBV) primarily replicates in epithelial cells of the upper respiratory tract of chickens, inducing both morphological and immune modulatory changes. However, the association between the local immune responses induced by IBV and the mechanisms of pathogenesis has not yet been completely elucidated. This study compared the expression profile of genes related to immune responses in tracheal samples after challenge with two Brazilian field isolates (A and B) of IBV from the same genotype, associating these responses with viral replication and with pathological changes in trachea and kidney. We detected a suppressive effect on the early activation of TLR7 pathway, followed by lower expression levels of inflammatory related genes induced by challenge with the IBV B isolate when compared to the challenge with to the IBV A isolate. Cell-mediated immune (CMI) related genes presented also lower levels of expression in tracheal samples from birds challenged with B isolate at 1dpi. Increased viral load and a higher percentage of birds with relevant lesions were observed in both tracheal and renal samples from chickens exposed to challenge with IBV B isolate. This differential pattern of early immune responses developed after challenge with IBV B isolate, related to the downregulation of TLR7, leading to insufficient pro-inflammatory response and lower CMI responses, seem to have an association with a most severe renal lesion and an enhanced capability of replication of this isolate in chicken.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kotani, T" uniqKey="Kotani T">T Kotani</name></author><author><name sortKey="Wada, S" uniqKey="Wada S">S Wada</name></author><author><name sortKey="Tsukamoto, Y" uniqKey="Tsukamoto Y">Y Tsukamoto</name></author><author><name sortKey="Kuwamura, M" uniqKey="Kuwamura M">M Kuwamura</name></author><author><name sortKey="Yamate, J" uniqKey="Yamate J">J Yamate</name></author><author><name sortKey="Sakuma, S" uniqKey="Sakuma S">S Sakuma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Okino, Ch" uniqKey="Okino C">CH 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Ganapathy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhong, Y" uniqKey="Zhong Y">Y Zhong</name></author><author><name sortKey="Tan, Yw" uniqKey="Tan Y">YW Tan</name></author><author><name sortKey="Liu, Dx" uniqKey="Liu D">DX Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vervelde, L" uniqKey="Vervelde L">L Vervelde</name></author><author><name sortKey="Matthijs, Mg" uniqKey="Matthijs M">MG Matthijs</name></author><author><name sortKey="Van Haarlem, Da" uniqKey="Van Haarlem D">DA van Haarlem</name></author><author><name sortKey="De Wit, Jj" uniqKey="De Wit J">JJ de Wit</name></author><author><name sortKey="Jansen, Ca" uniqKey="Jansen C">CA Jansen</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Brésil</li></country><region><li>Santa Catarina</li><li>État de São Paulo</li></region></list><tree><country name="Brésil"><region name="Santa Catarina"><name sortKey="Okino, Cintia Hiromi" sort="Okino, Cintia Hiromi" uniqKey="Okino C" first="Cintia Hiromi" last="Okino">Cintia Hiromi Okino</name></region><name sortKey="Brentano, Liana" sort="Brentano, Liana" uniqKey="Brentano L" first="Liana" last="Brentano">Liana Brentano</name><name sortKey="Coldebella, Arlei" sort="Coldebella, Arlei" uniqKey="Coldebella A" first="Arlei" last="Coldebella">Arlei Coldebella</name><name sortKey="Montassier, Helio Jose" sort="Montassier, Helio Jose" uniqKey="Montassier H" first="Hélio José" last="Montassier">Hélio José Montassier</name><name sortKey="Mores, Marcos Antonio Zanella" sort="Mores, Marcos Antonio Zanella" uniqKey="Mores M" first="Marcos Antônio Zanella" last="Mores">Marcos Antônio Zanella Mores</name><name sortKey="Trevisol, Iara Maria" sort="Trevisol, Iara Maria" uniqKey="Trevisol I" first="Iara Maria" last="Trevisol">Iara Maria Trevisol</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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